Changes of platelet activition and the effect of Composite Salviae Dropping Pill ( CSDP) in the treatment of childrenwith primary nephratic syndrome
Abstract：Objective To study the changes of platelet granule membrane protein - 140( GMP - 140) in children withprimary nephrotic syndrome ( PNS) and to evaluate the effects of Composite Salviae Dropping Pill( CSDP ) in treating the disease. Methods 42 PNS patients were randomly divided into two groups - CSDP treated group ( n = 22 ) and control treated group( n ＝20). CSDP was given to CSDP treated group orally for 8 weeks. Prednisone 2mg/( kg · d) and other conservative agents were given to both groups. 19 health children were served as normal control group. The levels of GMP140 was measured by ELISA. Results The results showed that the plasma level of GMP - 140 in PNS was significantly higher than that in control groups( P ＜0. 01 ). The level of GMP - 140 corresponded to the severity of PNS. Following the treatment, CMP- 140 level decreased significantly in CSDP group compared with that in control treated group( P ＜ 0.01 ).There was no significant difference in platelet count among the groups. Conclusion There finding indicate that there were elevated platelet activation in PNS,and CSDP may inhibit the activation of platelet,therefore improve the symptoms and cut off the development of PNS.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 14-16 )