Novel insights into non-coding RNAs and their role in hydrocephalus
Zhiyue Cui
Jian He
An Li
Junqiang Wang
Yijian Yang
Kaiyue Wang
Zhikun Liu
Qian Ouyang
Zhangjie Su
Pingsheng Hu
Gelei Xiao
Abstract：A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation. This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiological mechanisms underlying hydrocephalus, one of the most common neurological conditions worldwide. In this review, we first outline the basic concepts and incidence of hydrocephalus along with the limitations of existing treatments for this condition. Then, we outline the definition, classification, and biological role of non-coding RNAs. Subsequently, we analyze the roles of non-coding RNAs in the formation of hydrocephalus in detail. Specifically, we have focused on the potential significance of non-coding RNAs in the pathophysiology of hydrocephalus, including glymphatic pathways, neuroinflammatory processes, and neurological dysplasia, on the basis of the existing evidence. Lastly, we review the potential of non-coding RNAs as biomarkers of hydrocephalus and for the creation of innovative treatments.
Keywords：hydrocephalusneurodevelopmentneuroinflammationnon-coding RNAtherapeutic target
Publication Date：2026-02-28
Online Publishing Date：2025-12-09(First online date of this platform, not the publication date of the document)
Pages：12( 636-647 )