Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system
Marta García-Juan
Mario Villa
Irene Benito-Cuesta
Lara Ordóñez-Gutiérrez
Francisco Wandosell
Abstract：Autophagy is a cellular degradation and recycling system, indispensable for cellular and organ development, homeostasis, and function. This cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles, which finally recycle components as amino acids. This process is effective during normal physiology as part of anabolism and plays an additional important role during starvation (Dikic and Elazar, 2018). Different types of autophagy have been characterized based on their dynamic, mechanism of action, target substrates, and protein markers. Some of them are macroautophagy (hereafter called "autophagy"), microautophagy, and chaperone-mediated autophagy (Fleming et al., 2022).
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Publication Date：2025-11-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 3209-3210 )