Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function
William J.Flerlage
Mark L.Dell'Acqua
Brian M.Cox
Fereshteh S.Nugent
Abstract：There is strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders (Simmons et al., 2024). Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis, synaptic function, and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds, including the family of proteins known as A-kinase anchoring proteins (AKAPs).
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Publication Date：2025-10-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2913-2914 )