Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist
Nicolas Hugues
Yu Luo
Abstract：Adult microglia, by continuously sensing changes in their environment and communicating with nearly all brain cell types, are considered to be the immune sentinels of the brain. In the healthy central nervous system (CNS), microglia display a unique molecular homeostatic signature (i.e., Tmem119, P2ry12, Sall1, Siglech, Gpr34, and Hexb) (Figure 1A). These homeostatic microglia are distinct from activated microglia, the signature of which is highly microenvironment- and cellular context-dependent (Butovsky and Weiner, 2018; Paolicelli et al., 2022; Figure 1).
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Publication Date：2025-10-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2895-2897 )