Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems
Alena Salasova
Anders Nykjær
Abstract：The formation of the mammalian nervous system and its maturation into sensory, motor, cognitive, and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young adulthood. Impaired neurodevelopment can result in various neurological and psychiatric conditions, jointly named neurodevelopmental disorders (NDDs). Today's stringent NDD classification includes intellectual disabilities, communication disorders, autism spectrum disorder, attention-deficit hyperactivity disorder, movement disorders, and specific learning disorders. While the NDD incidence is on the rise, the available therapies are limited and provide only symptomatic relief (Cainelli and Bisiacchi, 2022).
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Publication Date：2025-09-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2591-2593 )