Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology
Mikio Shimizu
Tatsusada Okuno
Abstract：Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal cord. Patients with ALS develop skeletal muscle weakness, resulting in death from respiratory paralysis, which usually occurs 2-4 years after clinical onset (Goutman et al., 2022).
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Publication Date：2025-09-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2589-2590 )