Apolipoprotein E elicits target-directed miRNA degradation to maintain neuronal integrity
Jiazi Tan
Chin-Tong Ong
Abstract：Apolipoprotein E has diverse functions in neurons: Apolipoprotein E (ApoE) is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system. There are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions (Flowers and Rebeck, 2020). ApoE2 is characterized by Cys112 and Cys158, ApoE3 by Cys112 and Arg158, whereas ApoE4 contains Arg112 and Arg158.
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Publication Date：2025-09-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2577-2578 )