Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders
Asma Boulksibat
Alessandra Tempio
Barbara Bardoni
Abstract：The second messengers 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) modulate molecular pathways that are involved in a large variety of cellular processes. In the brain, these processes include neurogenesis, neuronal differentiation, activation and function of microglia, and synaptic plasticity, finally resulting in memory formation.
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Publication Date：2025-08-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2302-2303 )