Decoding molecular mechanisms:brain aging and Alzheimer's disease
Mahnoor Hayat
Rafay Ali Syed
Hammad Qaiser
Mohammad Uzair
Khalid Al-Regaiey
Roaa Khallaf
Lubna Abdullah Mohammed Albassam
Imdad Kaleem
Xueyi Wang
Ran Wang
Mehwish S.Bhatti
Shahid Bashir
Abstract：The complex morphological, anatomical, physiological, and chemical mechanisms within the aging brain have been the hot topic of research for centuries. The aging process alters the brain structure that affects functions and cognitions, but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease. Beyond these observable, mild morphological shifts, significant functional modifications in neurotransmission and neuronal activity critically influence the aging brain. Understanding these changes is important for maintaining cognitive health, especially given the increasing prevalence of age-related conditions that affect cognition. This review aims to explore the age-induced changes in brain plasticity and molecular processes, differentiating normal aging from the pathogenesis of Alzheimer's disease, thereby providing insights into predicting the risk of dementia, particularly Alzheimer's disease.
Keywords：Alzheimer's diseasebrain agingcognitive healthdementiamolecular mechanismsneuronal activityneuroplasticityneurotransmission
Publication Date：2025-08-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：21( 2279-2299 )