Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration
Bryan Sun
Lulin Li
Jian Luo
Abstract：The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has emerged as a key mediator of neuroinflammation. While current studies primarily attribute its effects to neurons and glial cells, emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature, particularly in brain endothelial cells. Therefore, studying the role of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic interventions. Here, we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.
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Publication Date：2025-07-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2005-2007 )