Cryptic exon inclusion in TDP-43 proteinopathies:opportunities and challenges
Lorena Decker
Sonja Menge
Axel Freischmidt
Abstract：TDP-43 proteinopathies and cryptic exons: Transactive response DNA binding protein of 43 kDa (TDP-43) is a ubiquitously expressed RNA/DNA binding protein crucial for coding and non-coding RNA metabolism including transcription, splicing, transport, translation, and turnover. TDP-43 shuttles between the nucleus and cytoplasm, but is predominantly localized in the nucleus. Neurodegenerative diseases (NDs) may be accompanied by nuclear loss and possible cytoplasmic accumulation and aggregation of TDP-43 in vulnerable neurons and beyond.
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Publication Date：2025-07-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2003-2004 )