Like a G6-nal:transcriptional control of G-protein coupled receptors during oligodendroglial development
Tim Aberle
Michael Wegner
Abstract：Multilayered control of myelination: Quick, saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating glia. In the central nervous system, this role is taken up by oligodendrocytes. Oligodendrocytes are marked by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells (OPCs) during embryonal stages. While the majority of OPCs differentiate into mature oligodendrocytes when nearby axonal segments require myelination, a small subpopulation of OPCs persist as a progenitor pool.
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Publication Date：2025-07-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2001-2002 )