Unraveling brain aging through the lens of oral microbiota
Qinchao Hu
Si Wang
Weiqi Zhang
Jing Qu
Guang-Hui Liu
Abstract：The oral cavity is a complex physiological community encompassing a wide range of microorganisms. Dysbiosis of oral microbiota can lead to various oral infectious diseases, such as periodontitis and tooth decay, and even affect systemic health, including brain aging and neurodegenerative diseases. Recent studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration, indicating potential avenues for intervention strategies. In this review, we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases, and dissect potential mechanisms by which oral microbes contribute to brain aging and neurodegeneration. We also highlight advances in therapeutic development grounded in the realm of oral microbes, with the goal of advancing brain health and promoting healthy aging.
Keywords：Alzheimer's diseasebrain agingmultiple sclerosisneurodegenerationneurodegenerative diseasesoral microbiotaParkinson's diseaseperiodontitisbacteriaPorphyromonas gingivalis
Publication Date：2025-07-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：14( 1930-1943 )