New insights on the role of chondroitin sulfate proteoglycans in neural stem cell-mediated repair in spinal cord injury
Seyed Mojtaba Hosseini
Soheila Karimi-Abdolrezaee
Abstract：Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al., 2019). Following the primary impact, the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood-spinal cord barrier, vascular injury, glial reactivity, neuroinflammation, oxidative stress, lipid peroxidation, and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death, demyelination, and axonal damage (Alizadeh et al., 2019).
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Publication Date：2025-06-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1699-1700 )