How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease
Livia La Barbera
Paraskevi Krashia
Annalisa Nobili
Abstract：Despite decades of dedicated research, Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are still unclear. AD is characterized by featured histological alterations including amyloid-beta (Aβ) plaque deposition, accumulation of neurofibrillary tangles of hyperphosphorylated-tau, and neuronal loss, accompanied by progressive cognitive decline and behavioral changes. The sporadic form of AD primarily affects old individuals (onset around 65 years), leading to difficulties in daily activities along the disease progression. According to the last World Alzheimer Report, the number of patients suffering from AD, together with the economic and social burdens related to the disease, are expected to rapidly increase in the following years.
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Publication Date：2025-05-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1405-1406 )