Cortical hem signaling center:functions,development,and potential implications for evolution and brain disorders
Victor V.Chizhikov
Igor Y.Iskusnykh
Abstract：Development of the telencephalon relies upon several signaling centers - localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium. One such signaling center is the cortical hem, which arises during embryonic development at the telencephalic dorsal midline, adjacent to the choroid plexus and hippocampal primordium (Figure 1A). While the cortical hem has also been described in reptiles and birds, most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.
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Publication Date：2025-04-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1079-1080 )