Mitochondria-cGAS-STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration
José M.Izquierdo
Abstract：The word "senescence" comes from the Latin senescens, meaning "to begin to age", and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of previously replication-competent cells. Many stress situations lead to senescence, including telomere shortening, genotoxic stress, oncogene- and oxidative-induced stress, and mitochondrial dysfunction (Mico et al., 2021). It is also characterized by a proinflammatory senescence-associated secretory phenotype (SASP) that potentiates chronic low-grade inflammation and inflammaging-associated dysfunction, resulting in loss of tissue function and health (Figure 1; Mico et al., 2021).
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Publication Date：2025-03-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 805-807 )