Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases
Minghuang Gao
Xinyue Wang
Shijie Su
Weicheng Feng
Yaona Lai
Kongli Huang
Dandan Cao
Qi Wang
Abstract：Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.
Keywords：central nervous systemmeningeal lymphatic vesselsimmunitymyeloid cellslymphatic cellsneurodegenerative disease
Publication Date：2025-03-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：16( 763-778 )