Context-dependent role of sirtuin 2 in inflammation
Noemí Sola-Sevilla
Maider Garmendia-Berges
MCarmen Mera-Delgado
Elena Puerta
Abstract：Sirtuin 2 is a member of the sirtuin family of NAD+-dependent deacetylases, known for its regulatory role in various processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3 (NLRP3). However, whether sirtuin 2-mediated pathways induce a pro- or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, studies on arthritis and type 2 diabetes mellitus suggest that sirtuin 2 is essential at the peripheral level, and thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.
Keywords：interferoninflammationlipopolysaccharideneuroinflammationNLRP3nuclear factor κBsirtuin 2
Publication Date：2025-03-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：13( 682-694 )