A lead role for a"secondary"axonal injury response
Melissa A.Rudy
Trent A.Watkins
Abstract：Stress signaling following axon injury stimulates a transcriptional program for regeneration that might be exploited to promote central nervous system repair. However, this stress response drives neuronal apoptosis in non-regenerative environments. This duality presents a quandary for the development of therapeutic interventions: manipulating stress signaling to enhance recovery of damaged neurons risks accelerating neurodegeneration or restricting regenerative potential. This dichotomy is well illustrated by the fates of retinal ganglion cells (RGCs) following optic nerve crush.
Machine-generated Keywords：
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 469-470 )