Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions
Narek Manukjan
Daniel Fulton
Zubair Ahmed
W.Matthijs Blankesteijn
Sébastien Foulquier
Abstract：As the population ages, the burden of age-related diseases becomes greater. Currently, over 55 million people suffer from dementia worldwide, with Alzheimer's disease being the most common form. However, it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease (cSVD) may be a more detrimental cause for dementia (Cuadrado-Godia et al., 2018). It is estimated that 10%-30% of the elderly population and 35%-90% of all dementia patients exhibit signs of cSVD. The term cSVD refers to pathology affecting the small vessels of the brain, which can lead to lacunar cerebral infarcts, enlarged perivascular spaces, and cortical hemorrhages (Cuadrado-Godia et al., 2018). CSVD is often associated with cognitive decline, gait problems, and dementia (Cuadrado-Godia et al., 2018). To minimize disease progression, preventive measures, and early interventions, such as risk factor management, are crucial. However, due to its asymptomatic nature, the disease is often silent and diagnosed coincidentally at later stages. Thus, the window of opportunity for prevention and treatment is often missed.
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Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 191-192 )