Comparing role of ATP between acute pain in neuromyelitis optica spectrum disorder and peripheral neuropathic pain
Teruyuki Ishikura
Tatsusada Okuno
Abstract：In this article, we present our previous research, which highlighted adenosine triphosphate (ATP) as the cause of neuropathic pain during the acute phase of neuromyelitis optica spectrum disorder (NMOSD). In NMOSD pathology, damage-associated molecular patterns (DAMPs), including ATP, are released from damaged astrocytes, triggering the activation of innate immune cells. ATP is a central mediator of acute pain in NMOSD. We delve into the mechanisms of ATP in peripheral neuropathic pain, drawing comparisons with our findings in NMOSD. Additionally, we address the intricacies of chronic pain associated with NMOSD.
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Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 184-185 )