Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior
Man Han
Deyang Zeng
Wei Tan
Xingxing Chen
Shuyuan Bai
Qiong Wu
Yushan Chen
Zhen Wei
Yufei Mei
Yan Zeng
Abstract：Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response. Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region-specific, particularly involving the corticolimbic system, including the ventral tegmental area, nucleus accumbens, prefrontal cortex, amygdala, and hippocampus. Determining how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress psychopathology. In this review, we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of depression. We focused on associated molecular pathways and neural circuits, with special attention to the brain-derived neurotrophic factor-tropomyosin receptor kinase B signaling pathway and the ventral tegmental area-nucleus accumbens dopamine circuit. We determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature, severity, and duration of stress, especially in the above-mentioned brain regions of the corticolimbic system. Therefore, BDNF might be a biological indicator regulating stress-related processes in various brain regions.
Keywords：amygdalachronic mild stresschronic social defeat stresscorticolimbic systemdepressionhippocampusmedial prefrontal cortexnucleus accumbenssocial stress modelsventral tegmental area
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：15( 159-173 )