Research progress in clinical application of intra-arterial thrombolysis after endovascular embolectomy for acute ischemic stroke
Huo Farong
Zhao Long
Tan Yafang
Li Junlian
Zhang Xiaoyan
Abstract：In recent years,study in reperfusion therapy for acute ischemic stroke(AIS)has made significant progress,endovascular embolectomy(EVT)has become the standardized treatment for patients with large vessel occlusion.However,the ineffective recanalization caused by microcirculation disturbance after successful recanalization has become the key limiting factor of the EVT treatment efficacy.Intra-arterial thrombolysis after successful recanalization of EVT has become a novel treatment strategy targeting at the possible microcirculation disturbance caused by residual thrombus.Based on the latest research progress,this paper summarized the drug application strategy,safety,effectiveness,translational challenges and future direction of intra-arterial thrombolysis after endovascular embolectomy for AIS.
Keywords：Ischemic strokePost-bridging therapyInvalid reconnectionReview
Publication Date：2025-12-18
Online Publishing Date：2025-12-29(First online date of this platform, not the publication date of the document)
Pages：6( 872-877 )