Research advances in cerebral proliferative angiopathy
Li Yi
Ma Yongjie
Qin Ao
Zhang Hongqi
Su Xin
Abstract：Cerebral proliferative angiopathy(CPA)was initially regarded as a variant of arteriovenous malformation.However,its distinct histological,angiographic,and pathophysiological features have led to its reclassification as an independent entity.CPA is an exceptionally rare form of cerebral vascular malformation,its pathogenesis is primarily linked to diffuse vascular proliferation secondary to chronic hypoperfusion.Clinically,CPA presents with a heterogeneous spectrum of manifestations,most commonly severe headaches and epileptic seizures.Neuroimaging(MR)typically reveals a complex interplay of aberrant vessels within the brain parenchyma,which may complicate the clinical management and lead to a higher rate of poor prognosis.This article reviewed current knowledge on the pathogenesis,epidemiology,clinical features,diagnostic approaches,and treatment options for CPA,with the aim of enhancing understanding of its underlying mechanisms and guiding future therapeutic strategy optimizations.
Keywords：Cerebral proliferative angiopathyClinical manifestationsPathogenesisReview
Publication Date：2025-11-18
Online Publishing Date：2025-12-02(First online date of this platform, not the publication date of the document)
Pages：8( 777-784 )