Research progress on pyroptosis in subarachnoid hemorrhage
Sun Bowen
Lan Shuai
Wang Xi'ao
Xu Shancai
Shi Huaizhang
Abstract：Subarachnoid hemorrhage(SAH)is a major subtype of stroke,characterized by high mortality and disability rates.Pyroptosis,a form of programmed cell death,has been identified as a key pathological process in early brain injury.Current research indicates that pyroptosis can occur in neurons,microglia,astrocytes,and cerebral vascular endothelial cells after SAH,leading to neurological dysfunction,brain edema,and disruption of the blood-brain barrier.The NOD-like receptor protein 3(NLRP3)inflammasome is regarded as a central regulatory component of pyroptosis,and its activation mechanisms and roles in various cell types have become focal points of research.A variety of therapeutic strategies targeting this pathway have emerged,including NLRP3 inhibitors,Caspase-1 inhibitors,and Gasdermin-D inhibitors.The aforemenetioned approaches all have demonstrated efficacy in animal studies.Additionally,novel technologies such as stem cell therapy,exosome therapy,and gas therapy offer novel intervention approaches for modulating pyroptosis.Although,various therapeutic strategies targeting pyroptosis-related pathways have emerged in recent years,a comprehensive summary remains absent.This article reviewed the advancements in pyroptosis research following SAH and associated treatment strategies,aiming to provide a theoretical foundation for subsequent mechanistic studies and clinical translation.
Keywords：Subarachnoid hemorrhagePyroptosisInflammasomeNLR familypyrin domain-containing 3 proteinNeuroinflammationReview
Publication Date：2025-05-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 349-355 )