Research progress on the molecular mechanism of the relationship between macrophages and acute ischemic stroke
Zhang Yongshun
Zhao Feng
Sun Meng
Li Zhiqiang
Abstract：The relationship between macrophages and acute ischemic stroke is currently a research hotspot.Previous studies have shown that macrophages in the central nervous system,vascular wall,and circulatory system can affect acute ischemic stroke through different mechanisms such as exacerbating inflammatory responses,phagocytosis,or inducing ferroptosis of vascular endothelial cells.In addition,during the occurrence of acute ischemic stroke,macrophages in the vascular wall and circulating system play a significant role through exosomes.This article reviewed the pathogenic mechanisms of macrophages in acute ischemic stroke,with the aim of providing a reference for in-depth research on the relationship between macrophages and acute ischemic stroke and the development of precise treatment plans.
Keywords：MacrophageAcute ischemic strokeExosomeFerroptosisReview
Publication Date：2025-04-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 285-290 )