Regulating effect and therapeutic potential of intestinal flora in gastrointestinal dysfunction of post-stroke
Wang Xueting
Wang Pengqin
Abstract：Stroke is a common central nervous system disease,with over 50％of stroke survivors experiencing gastrointestinal dysfunction,such as dysphagia,gastrointestinal bleeding,bowel obstruction,constipation,and fecal incontinence,which can lead to poor prognosis and increased mortality.In recent years,the interaction between the brain and gut has been a hot topic of research.Bidirectional communication between the brain and gut post-stroke can trigger changes in the gut microbiota,thereby affecting intestinal barrier function,immune activation,and metabolic products.Therefore,restoring the health and diversity of gut microbiota is crucial for the prevention and treatment of post-stroke gastrointestinal dysfunction.The authors reviewed the gastrointestinal complications following stroke,the changes in gut microbiota,and their impact on gastrointestinal function,and summarized relevant research advancements targeting gut microbiota as a therapeutic approach,with the aim of providing new insights for clinical treatment.
Keywords：StrokeGastrointestinal microbiomeGastrointestinal dysfunctionGut-brain-microbiota axisReview
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 57-62,73 )