Recent advances in the role and regulatory mechanisms of aquaporin 4 in ischemic stroke
Wu Xiaomei
Peng Linhui
Li Kongping
Zuo Xialin
Abstract：As the main water channel expressed in the brain,aquaporin 4(AQP4)has been implicated in the pathological process of ischemic stroke.After ischemic stroke,the expression,phosphorylation and polarity distribution of AQP4 are affected by the process of transcription and post-translational modification.The paper summarized the basic structure,physiological function,dynamic expression changes and mechanisms of AQP4 in this review,specifically discussing the role of AQP4 in cerebral edema,blood-brain barrier permeability and neuroinflammation after ischemic stroke,offering an up-to-date perspective on further effective therapeutic strategies for ischemic stroke.
Keywords：Aquaporin 4Ischemic strokeBrain edemaBlood-brain barrierNeurogliaNeuroinflammationReview
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 693-699 )