Research progress of cyclic AMP-activated exchange protein 1/RAS-related protein 1 signal pathway in the pathogenesis of cerebral ischemia-reperfusion injury
Lyu Xue
Sun Yihong
Hua Zhipeng
Jia Jianxin
Abstract：Cerebral ischemia-reperfusion injury(CIRI)is a serious complication caused by the recovery of blood flow in the affected brain tissue of patients with ischemic stroke.CIRI patients are often accompanied by neurological dysfunction,cognitive impairment,emotional disorders and other symptoms,which have a serious impact on daily life.At present,CIRI is easy to be diagnosed early,but there are relatively few related specific treatments.In this paper,the correlation between cyclic adenylate-activated exchange protein 1/RAS-related protein 1(Epac1/Rap1)signaling pathway and CIRI is reviewed,in order to provide new ideas for clinical treatment of CIRI patients.
Keywords：Cerebral ischemia-reperfusion injuryEpac1/Rap1 signaling pathwayPathogenesisReview
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 552-558 )