Expression of lncRNA SNHG5 and miR-212-3p in malignant meningioma tissues and their correlation with clinicopathological features and prognosis of patients
GUO Cuixia
ZHAO Juncang
LIU Xiaoying
ZHU Xu
Abstract：Objective To investigate the expression levels of long non-coding RNA(lncRNA)small nucleolar RNA host gene 5(SNHG5)and microRNA-212-3p(miR-212-3p)in malignant meningioma tissues and their correlation with clinicopathological features and prognosis of patients.Methods Ninety-eight cases of malignant meningioma were pro-spectively collected at Handan Central Hospital from January 2018 to March 2021.Real-time quantitative PCR was used to detect the expression levels of lncRNA SNHG5 and miR-212-3p in tumor tissues and adjacent tissues.All patients were fol-lowed up for 36 months postoperatively.Results Compared with adjacent tissues,malignant meningioma tissues showed significantly increased expression levels of lncRNA SNHG5(P<0.001)and significantly decreased expression levels of miR-212-3p(P<0.001).The bioinformatics software Starbase predicted binding sites between lncRNA SNHG5 and miR-212-3p.Pearson correlation analysis revealed a significant negative correlation between the expression levels of lncRNA SNHG5 and miR-212-3p in malignant meningioma tissues(r=-0.557,P<0.001).The expression levels of lncRNA SNHG5 and miR-212-3p were closely associated with tumor invasion type and extracranial metastasis(P<0.001),but showed no significant correlation with patient gender,age,tumor location,tumor size,pathological tumor type,or degree of peritumoral edema(P>0.05).During the 36-month postoperative follow-up,41 patients died,with a mortality rate of 41.8%.Multivariate Cox proportional hazards regres-sion analysis indicated that high expression of lncRNA SNHG5 and low expression of miR-212-3p were independent risk factors for death in patients with malignant meningioma(P<0.05).Kaplan-Meier survival curve analysis demonstrated that the median survival time was significantly longer in patients with low lncRNA SNHG5 expression compared to those with high expression(P<0.001),and significantly shorter in patients with low miR-212-3p expression compared to those with high expression(P<0.001).Conclusion The expression of lncRNA SNHG5 is upregulated while that of miR-212-3p is downregulated in malignant menin-gioma tissues.Both are closely associated with tumor invasion,extracranial metastasis,and patient survival prognosis.
Keywords：malignant meningiomalong non-coding RNA small nucleolar RNA host gene 5(lncRNA SNHG5)microRNA-212-3p(miR-212-3p)clinicopathological featuressurvival prognosis
Publication Date：2025-12-25
Online Publishing Date：2026-02-02(First online date of this platform, not the publication date of the document)
Pages：5( 733-737 )