Relationship between serum sVCAM-1 and CGRP levels and cerebral vasospasm after aneurysmal subarachnoid haemorrhage
HE Jian-hui
DONG Hai-qing
WANG Wei-lin
XIE Dong
Abstract：Objective To investigate the changes in serum levels of soluble vascular cell adhesion molecule-1(sVCAM-1)and calcitonin gene-related peptide(CGRP)in patients with aneurysmal subarachnoid hemorrhage(aSAH)and their predictive value for cerebral vasospasm(CVS).Methods From April 2022 to April 2024,145 aSAH patients were prospectively enrolled,and 105 healthy individuals undergoing physical examination during the same period were selected as the control group.Serum levels of sVCAM-1 and CGRP were measured using ELISA.CVS was diagnosed if transcranial Doppler ultrasound showed a mean blood flow velocity in the middle cerebral artery>140 cm/s.Results Compared with the control group,aSAH patients had significantly higher serum sVCAM-1 levels(P<0.001)and significantly lower serum CGRP levels(P<0.001).Among the 145 aSAH patients,51 developed CVS,with an incidence rate of 35.17%.Multivariate logistic regression analysis showed that elevated serum sVCAM-1 levels were an independent risk factor for CVS in aSAH patients(OR=2.798,95%CI 1.406～5.567,P=0.003),while elevated serum CGRP levels were a protective factor against CVS in aSAH patients(OR=0.745,95%CI 0.620～0.896,P=0.002).ROC curve analysis revealed that the combination of serum sVCAM-1≥204.81 ng/mL and serum CGRP≤20.83 pg/mL predicted CVS in aSAH with an area under the curve of 0.947(95%CI 0.886～0.981),a sensitivity of 89.47%,and a specificity of 91.55%.Conclusion aSAH patients exhibit increased serum sVCAM-1 levels and decreased serum CGRP levels,which are closely associated with CVS.Combined detection of serum sVCAM-1 and CGRP has high predictive value for CVS following aSAH.
Keywords：Aneurysmal subarachnoid hemorrhageCerebral vasospasmSerum markersSoluble vascular cell adhesion molecule-1Calcitonin gene-related peptide
Publication Date：2025-07-25
Online Publishing Date：2025-09-28(First online date of this platform, not the publication date of the document)
Pages：6( 413-418 )