Efficacy of endovascular intervention combined with human urinary kallidinogenase in the treatment of acute ischemic stroke

EKBEL Gamali; LU Xiao-hui; CHECLER Ablikon; WU Xin-shan; CHEN Shi-bao; ZHAO Jing

doi:10.13798/j.issn.1009-153X.2025.03.007

Abstract：Objective To investigate the efficacy of endovascular intervention combined with human urinary kallidinogenase in the treatment of acute ischemic stroke.Methods The clinical data of 91 patients with acute ischemic stroke admitted between July 2021 and July 2023 were retrospectively analyzed.Forty-five patients underwent endovascular intervention alone(control group),while 46 patients received additional intravenous human urinary kallidinogenase for 2 weeks post-intervention(observation group).At 2 weeks post-treatment,neurological function was assessed using the National Institutes of Health Stroke Scale(NIHSS),efficacy was evaluated via the modified Rankin Scale(mRS)and Barthel Index(BI),serum levels of homocysteine(HCY),central nervous system-specific protein(S100β),and lipoprotein-associated phospholipase A2(Lp-PLA2)were measured,and cerebral blood flow was analyzed using color Doppler ultrasound.Results At 2 weeks post-treatment,both groups showed significant improvements in NIHSS,mRS,and BI scores(P<0.05),with the observation group outperforming the control group(P<0.05).Serum HCY,S100β,and Lp-PLA2 levels,as well as cerebral blood flow,significantly improved in both groups(P<0.05),with the observation group demonstrating superior outcomes(P<0.05).No statistically significant differences were observed in the incidence of complications such as dizziness,palpitations,or hypotension between the two groups(P>0.05).Conclusion For acute ischemic stroke,combining endovascular intervention with intravenous human urinary kallidinogenase effectively reduces inflammatory responses,improves vascular endothelial function and cerebral blood flow,protects neurological function,enhances clinical efficacy,and demonstrates favorable safety.