Role of exosomal circular RNA in the tumorigenesis and development of glioma
SONG Lü-meng
LI Shun
XIONG Ping
CHENG Yin-chuan
XIA Xiao-chao
WANG Zi-hao
Abstract：Glioma is the most common and lethal primary malignant tumor of the central nervous system.At present,the treatment methods for glioma mainly adopt comprehensive treatments such as surgical resection combined with radiotherapy and chemotherapy.Nevertheless,almost all malignant gliomas will relapse after surgery,and the rates of chemotherapy resistance and radiotherapy resistance are high.Hence,exploring the molecular mechanisms of glioma occurrence and development and seeking new therapeutic targets are of paramount significance.Exosomes are extracellular vesicles involved in intercellular information communication,carrying various substances such as proteins,nucleic acids,and lipids,and playing a crucial role in the tumor microenvironment.Circular RNA(circRNA)is a type of stable non-coding RNA that can be carried by exosomes and functions as a microRNA(miRNA)sponge,exerting an important role in the occurrence and development of glioma.This article reviews the latest research progress of exosomal circRNA in aspects such as glioma proliferation and migration,angiogenesis,and drug resistance,and expounds on its value in clinical application.
Keywords：GliomaExosomeCircular RNA
Publication Date：2024-12-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 761-766 )