Expression and significance of HJURP in human glioma:a bioinformatics analysis based on the CGGA database
SUN Yu-chen
YANG Sheng-wei
WANG Hui-juan
Abstract：Objective To explore the expression of Holliday Junction Recognition Protein(HJURP)in human glioma and its association with clinical,pathological characteristics,and prognosis of patients.Methods The mRNAseq-325 dataset containing RNA-seq data and clinical information of 325 glioma cases was retrieved from the Chinese Glioma Genome Atlas(CGGA)database by computer.The dataset of 693 glioma cases in mRNAseq-693 was utilized for validation.The relationship between the expression of HJURP and the clinical and pathological characteristics of glioma was analyzed using R language software.Kaplan-Meier survival analysis was employed to assess the influence of HJURP expression on the survival of human glioma.Results The expression level of HJURP in glioma was significantly upregulated(P<0.05);its expression level was correlated with the IDH genotype of glioma,1p19q co-deletion status,and WHO pathological grade(P<0.0001),but not significantly related to MGMT promoter methylation(P>0.05).Kaplan-Meier survival curve analysis demonstrated that the HJURP low-expression group exhibited a significant survival advantage compared to the HJURP high-expression group(P<0.0001).GO,KEGG,and GSVA analyses revealed that HJURP was involved in the regulation of mitosis,cell cycle,and chromosome segregation in glioma cells.Conclusion HJURP is aberrantly highly expressed in human glioma and is associated with an unfavorable prognosis.This indicates that HJURP can serve as a biomarker for human glioma.
Keywords：GliomaHolliday junction recognition proteinClinical characteristicsPathological characteristicsPrognosis
Publication Date：2024-12-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 724-728 )