Research advances on the function of Notch signaling pathway in glioma
XIA Xiao-chao
WANG Zi-hao
XIONG Ping
SONG Lü-meng
CHENG Yin-chuan
LI Shun
Abstract：The Notch signaling pathway,functioning as a critical intercellular signaling conduit,exerts a vital role in the development and homeostasis maintenance of diverse tissues and organs.Once the Notch receptor undergoes three proteolytic cleavages,its intracellular domain(NICD)translocates to the nucleus and governs the transcriptional expression of a series of target genes.Researches conducted in recent years have indicated that the aberrant activation of the Notch signaling pathway is closely associated with the genesis and progression of tumors,particularly in glioma.The excessive activation of the Notch signaling pathway not only promotes the proliferation and invasion of tumor cells but also influences the tumor microenvironment and maintains the homeostasis of glioma stem cells.Consequently,the Notch signaling pathway is regarded as one of the potential therapeutic targets for glioma.Despite the fact that there have been studies reporting the treatment of glioma by inhibiting the Notch signaling pathway,the clinical efficacy of existing drugs still requires further validation.With the in-depth investigation of the mechanism of the Notch signaling pathway in glioma,this pathway is anticipated to offer novel strategies and notions for the treatment of glioma.This article will review the mechanism of the Notch signaling pathway in glioma and its latest research advancements.
Keywords：Notch signaling pathwaygliomaTumor MicroenvironmentTumor stem cells
Publication Date：2024-11-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 686-689 )