Research progress of targeted anti-inflammatory therapy for carotid atherosclerosis
LI Yong-yong
ZHAO Kai-sheng
Abstract：Carotid atherosclerosis(CAS)is a disease driven by chronic inflammation.Inflammatory factors and recurrent inflammatory responses contribute to the gradual thickening of carotid atherosclerotic plaques,thereby exacerbating the degree of carotid stenosis and elevating the risk of ischemic stroke.Currently,in the clinical setting,the assessment of plaque size or the degree of lumen stenosis is predominantly employed to determine the risk of vascular stenosis induced by carotid atherosclerotic plaques and vascular occlusion resulting from plaque rupture.Although reducing low-density lipoprotein cholesterol(LDL-C)serves as the principal pharmacological treatment for preventing and inhibiting the progression of CAS at present,even with the maximal reduction of LDL-C levels,the occurrence of major adverse cerebrovascular events cannot be completely precluded.This might be associated with the crucial role of inflammation in promoting carotid plaque rupture.Hence,CAS demands more precise rupture risk assessment,effective prevention strategies,and superior treatment approaches.This article reviews the relationship between inflammatory factors and CAS as well as the research progress of anti-inflammatory therapy.
Keywords：Carotid atherosclerosisInflammatory factorsTargeted anti-inflammatory therapy
Publication Date：2024-11-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 682-685 )