Research status of circular RNA in DNA damage repair of glioma
LI Pei-heng
PENG Biao
Abstract：Glioma is a tumor of the central nervous system characterized by high malignancy,high recurrence rate,and poor prognosis.DNA damage repair plays a vital role in the genesis and progression of glioma and significantly influences the efficacy of radiotherapy and chemotherapy.Circular RNA(circRNA)is a type of single-stranded closed-loop non-coding RNA,possessing high conservation and tissue specificity.It can impact the occurrence,development,and therapeutic outcome of glioma by regulating the DNA damage repair process.This paper summarizes the pathophysiological mechanisms by which circRNAs regulate DNA damage repair and explores their therapeutic prospects in DNA damage repair of glioma.
Keywords：GliomaDNA damage repairCircular RNA(circRNA)
Publication Date：2024-10-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 629-632 )