Anterolateral capsulotomy for mental retardation accompanied by severe behavioral disorders:a case report and literature review
JIANG Zhi-feng
DUAN Lei-mei
LIU Hui
WANG Li-hua
Abstract：Objective To evaluate the efficacy of anterolateral capsulotomy(AC)for patients with mental retardation accompanied by severe behavioral disorders.Methods A retrospective analysis was conducted on the clinical data of a patient with mental retardation associated with severe behavioral disorders who underwent stereotactic AC,and the related literatures were reviewed.Results This paper reports a 29-year-old male,a premature infant,who had mental retardation since childhood and intermittent behavioral disorders such as restlessness and shouting.Antipsychotic drugs were taken for a long time for control.One and a half years ago,the effect of drug treatment deteriorated and the symptoms worsened.After thorough evaluation,stereotactic bilateral single-target lesioning of the anterior limb of the internal capsule was performed.After the operation,the symptoms of behavioral disorders disappeared,the mood was stable,and magnesium valproate sustained-release tablets were continued.Within 3 to 6 months after the operation,there was no recurrence of symptoms,and the drugs were stopped.At the 42-month follow-up,the surgical effect remained good.Conclusion For mental retardation associated with severe behavioral disorders,if the effect of drug control is poor,AC can be considered.Due to the irreversibility of lesioning and issues related to ethics,it is particularly important to rationally select surgical patients and strictly grasp the surgical indications.It is recommended to closely collaborate with psychiatrists,ethicists,etc.
Keywords：Mental retardationBehavioral disordersAnterolateral capsulotomyEfficacy
Publication Date：2024-10-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 605-607 )