Effect of hyperbaric oxygen treatment on serum inflammatory markers of patients with severe traumatic brain injury complicated with pulmonary infection
GUO Bo-sheng
ZHAO Zhen-sheng
MIN Cui-li
LIU Xu-chang
CHANG Qing
ZHANG Wei
Abstract：Objective To explore the effect of hyperbaric oxygen(HBO)treatment on inflammatory markers including serum C-reactive protein(CRP),procalcitonin(PCT),and endotoxin in patients with severe traumatic brain injury(sTBI)complicated with pulmonary infection.Methods From June 2020 to March 2022,60 patients with sTBI combined with pulmonary infection were prospectively collected and divided into a control group and an observation group,with 30 cases in each group.The control group received conventional treatments such as reducing intracranial pressure and applying antibiotics,while the observation group received HBO therapy in addition to the treatment of the control group.The levels of serum CRP,PCT,and endotoxin in the two groups were compared before treatment and 1 to 6 weeks after treatment.Results Before treatment,there was no statistically significant difference in the levels of serum CRP,PCT,and endotoxin between the two groups(P>0.05).From 1 to 6 weeks after treatment,the three serum inflammatory markers in both groups decreased significantly(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).Conclusion HBO treatment can rapidly reduce the levels of serum CRP,PCT,and endotoxin in patients with sTBI complicated with pulmonary infection,suggesting that combined monitoring of these three indicators can guide the treatment of patients with sTBI complicated with pulmonary infection.
Keywords：Severe traumatic brain injuryPulmonary infectionHyperbaric oxygenSerumC-reactive proteinProcalcitoninEndotoxin
Publication Date：2024-10-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 590-594,598 )