Correlation between the early peripheral blood inflammatory markers after hemorrhage and the clinical outcome of aneurysmal subarachnoid hemorrhage
DING Rui
LIU Xi-zhi
ZHAO Zi-long
CHEN Zhi-biao
XIE Teng
WU Li-quan
Abstract：Objective To investigate the relationship between the early peripheral blood inflammatory markers and the delayed cerebral ischemia(DCI)as well as the clinical prognosis of patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods A total of 44 patients with aSAH that met the criteria were prospectively collected from December 2022 to December 2023.Peripheral blood inflammatory markers were detected within 24 hours of admission.Three months after the onset,prognosis was evaluated based on the Glasgow Outcome Scale(GOS)score,with a score of 4～5 indicating a favorable prognosis.Results Of the 44 patients,8 patients developed DCI,with an incidence rate of 18.2%.Three months after the onset,the GOS scores were 1 point for 2 cases,2 points for 3 cases,3 points for 4 cases,4 points for 2 cases,and 5 points for 33 cases;the favorable prognosis rate was 79.55%.Univariate logistic analysis revealed that white blood cell(WBC),neutrophil,blood glucose,neutrophil-to-lymphocyte ratio(NLR),systemic immune-inflammation index(SIRI),Hunt-Hess grade at admission,and modified Fisher grade at admission were the influencing factors for DCI in aSAH patients(P<0.05);WBC,neutrophil,triglyceride,blood glucose,NLR,SIRI,inflammatory prognostic index,Hunt-Hess score,and Fisher score at admission were the influencing factors for poor prognosis of aSAH(P<0.05).ROC curve analysis indicated that the level of interleukin-10 in peripheral blood had predictive value for poor prognosis in aSAH patients,with an area under the curve of 0.749(95%CI 0.560～0.938;P=0.022),the optimal cut-off value being 7.21 pg/ml,the sensitivity being 0.667,and the specificity being 0.829.Conclusions Peripheral blood inflammatory indicators are associated with DCI and clinical prognosis after aSAH,and the level of IL-10 in peripheral blood has favorable predictive value for the prognosis of aSAH.
Keywords：Aneurysmal subarachnoid hemorrhageInflammatory markersPeripheral bloodDelayed cerebral ischemiaPronosis
Publication Date：2024-10-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 586-589,615 )