Efficacy of hyperbaric oxygen treatment combined with aspirin in adult ischemic moyamoya disease-related headache
WANG Yu
YIN Zhen-sheng
LU Tao
CHEN Yang
HUAN Lin-chun
LIU Yu-hai
GONG Jian
LI Bing
Abstract：Objective To explore the efficacy of hyperbaric oxygen (HBO) treatment combined with aspirin in adult ischemic moyamoya disease (MMD)-related headache. Methods From March 2011 to January 2022,48 adult patients with MMD-related headache were prospectively collected. The patients were divided into the control group (n=20) and the combined treatment group (n=28) based on their treatment preferences. The control group underwent HBO treatment alone (1 session/day,5 sessions/week for 4 weeks),while the combined treatment group received HBO treatment plus aspirin treatment (100 mg/day). The Numerical Rating Scale (NRS) was employed to assess the pain condition,and adverse reactions as well as cerebral infarction,cerebral hemorrhage,and transient ischemic attack (TIA) were observed. Results After 4 weeks of treatment,the NRS score in the combined treatment group[(1.81±1.95) points]was significantly lower than that[(5.94±1.68) points]in the control group (P<0.001);the total effective rate in the combined treatment group (85.7％) was significantly higher than that (20.0％) in the control group (P<0.001). During the pressure increase process of HBO treatment,one case presented with ear distension (considered as barotrauma) causing the pressure increase immediately halted,after multiple Eustachian tube decompression maneuvers,the ear distension vanished and HBO treatment was resumed;five cases experienced tinnitus and ear distension and continued HBO treatment after symptomatic treatment. In the control group,there was 1 new case of cerebral infarction,1 new case of cerebral hemorrhage,and 3 cases of TIA;in the treatment group,there was 1 case of TIA,and no new cases of cerebral infarction or cerebral hemorrhage. The total incidence of complications in the combined treatment group ( 3.6％) was significantly lower than that (25.0％) in the control group (P=0.039). Conclusion HBO treatment combined with aspirin can effectively alleviate MMD-related headache and significantly reduce the incidence of cerebrovascular events.
Keywords：Moyamoya diseaseHeadacheHyperbaric oxygen therapyAspirinEfficacy
Publication Date：2024-09-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 527-531 )