Research advances of high-frequency oscillations based on magnetoencephalography in intractable epilepsy
BU Jin-xin
ZHU Hai-tao
XU Hong-hao
ZHANG Rui
Abstract：Epilepsy is a clinical syndrome resulting from highly synchronized abnormal discharges of neurons caused by multiple factors.Most epilepsy can be effectively controlled through drug treatment;however,a portion of epilepsy patients show a poor response to antiepileptic drug therapy and have difficult-to-control seizures,which are referred to as refractory epilepsy.Currently,epilepsy focus resection is the main treatment method for refractory epilepsy,and the key to a successful resection lies in the accurate identification of the epileptogenic focus.Nevertheless,accurately locating the epileptogenic focus has consistently been a challenge in neurosurgery.Previously,the epileptogenic focus was mainly located through spike waves in the electroencephalogram (EEG).In 2006,high-frequency oscillations was found in the intracranial EEG of patients with focal epilepsy.In recent years,research has indicated that high-frequency oscillations can delineate the boundaries of the epileptogenic focus more specifically than spike waves and can serve as a new physiological marker of the epileptogenic focus.This article primarily reviews the research progress of high-frequency oscillations based on magnetoencephalography in refractory epilepsy.
Keywords：Drug resistant epilepsyHigh frequency oscillationsMagnetoencephalogram
Publication Date：2024-08-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 491-494 )