Expression and prognostic significance of SERPINH1 gene in glioma
LIU Yuan-yuan
ZHAO Guang-rui
LI Bang-an
CHEN Guang-gui
WU Yong-hui
ZHOU Jin-xu
Abstract：Objective To explore the relationship between the expression of SERPINH1 gene and the prognosis of patients with glioma. Methods The TCGA,GTEx,CGGA,and HPA databases were retrieved by computer,and the expression levels of SERPINH1 mRNA and protein in glioma and normal tissues were analyzed using the online tools Ualcan and GEPIA. Subsequently,the sequencing data of mRNAseq_693 and mRNAseq_325 of glioma samples and their clinical data were obtained from the CGGA database,and prognosis analysis was conducted using R software. Results Compared with normal tissues,the expression of SERPINH1 in glioma tissues was significantly upregulated;furthermore,the higher the pathological grade of glioma,the higher the expression level of SERPINH1. The expression level of SERPINH1 in glioma was closely related to IDH mutation and 1p19q deletion (P<0.05). High expression of SERPINH1 was an independent risk factor for poor prognosis in patients with glioma. Conclusion SERPINH1 is highly expressed in glioma and is associated with poor prognosis of glioma patients. This indicates that SERPINH 1 can be served as a biomarker for the prognosis of patients with glioma.
Keywords：GliomaSERPINH1Gene expressionPrognosis
Publication Date：2024-07-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 411-414 )