Value of serum levels of PCT,IL-6 and MIP-2 in assessing secondary pulmonary infection in patients with severe traumatic injury after tracheotomy
ZONG Qing-hua
Zhang Hui
Liang A-ming
Li Ya-fei
Abstract：Objective To explore the value of serum levels of procalcitonin (PCT),interleukin-6 (IL-6),and macrophage inflammatory protein-2 (MIP-2) in assessing pulmonary infection in patients with severe traumatic injury (sTBI) after tracheotomy. Methods One hundren and fifty-five patients with sTBI were prospectively collected From May 2020 to October 2021. Tracheotomy was performed on the day of admission. Serum PCT,IL-6,and MIP-2 levels were detected before tracheotomy and on days 1,3,and 5 after tracheotomy,and the pulmonary infection within 1 week of admission was recorded. Results Within 1 week of admission,86 patients were diagnosed with pulmonary infection,and the incidence of pulmonary infection was 59.31％ (86/145). The levels of serum PCT,IL-6,and MIP-2 in patients with pulmonary infection significantly increased on days 3 and 5 after tracheotomy (P<0.05). ROC curve analysis showed that the area under the curve (AUC) for assessing pulmonary infection using the increased levels of serum PCT,IL-6,and MIP-2 on day 3 after tracheotomy was 0.907 (95％ CI 0.848～0.949),with a sensitivity of 96.51％,specificity of 76.27％,and accuracy of 88.28％;the AUC for assessing pulmonary infection using the increased levels of serum PCT,IL-6,and MIP-2 on day 5 after tracheotomy was 0.898 (95％ CI 0.837～0.942),with a sensitivity of 94.19％,specificity of 74.58％,and accuracy of 86.21％ . The Kappa values for the consistency between the assessment of pulmonary infection using the increased levels of serum PCT,IL-6,and MIP-2 on days 3 and 5 after tracheotomy and the clinical diagnosis results were 0.750 and 0.706,respectively. Conclusion When pulmonary infection occurs after tracheotomy in patients with sTBI,the levels of serum PCT,IL-6,and MIP-2 increase significantly. Therefore,monitoring the levels of serum PCT,IL-6,and MIP-2 is helpful for the early clinical diagnosis of pulmonary infection in patients with sTBI after the tracheotomy.
Keywords：Severe traumatic injuryTracheotomyPulmonary infectionSerumProcalcitoninInterleukin-6Macrophage inflammatory protein-2
Publication Date：2024-07-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 400-404,410 )