Expression of BMAL1 in peritumoral edema tissues of diffuse gliomas and its clinical implications
GUO Ying-chun
WANG Yu
ZHANG Zhi-xin
WANG Lei
Abstract：Objective To investigate the expression of brain and muscle ARNT-like 1(BMAL1)in the peritumoral edema tissues of diffuse gliomas and its clinical significance.Methods The BMAL1 expression levels were detected by immunohistochemical staining in the peritumoral edema tissues obtained from 64 patients with diffuse gliomas who underwent surgical resections between June 2021 and January 2023.Preoperative brain MRI was conducted,and the edema index was calculated to assess the severity of peritumoral edema.Results All 64 cases presented peritumoral edema,with 20 mild,9 moderate,and 35 severe edema.High BMAL1 expression was observed in 39 patients,and low expression in 25.The immunohistochemical staining score for BMAL1 in the peritumoral edema tissues showed a significant positive correlation with the edema index(r=0.408;95%CI 0.179～0.594;P<0.001).Multivariate logistic regression analysis revealed that high BMAL1 expression independently predicted severe peritumoral edema(OR=5.558;95%CI 1.897～8.467;P<0.001).Conclusions The level of BMAL1 expression in peritumoral edema tissues is positively correlated with the degree of peritumoral edema in diffuse gliomas,suggesting potential involvement of BMAL1 in the occurrence and progression of peritumoral edema.
Keywords：Diffuse gliomasPeritumoral edemaBrain and muscle ARNT-like 1(BMAL1)Risk factors
Publication Date：2024-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 218-221 )