Research progress of neuroprotective effect of exosomes derived from mesenchymal stem cells on cerebral ischemia-reperfusion injury
HAN Shuo
WANG Jun-yu
LU Cheng-yin
HOU Li-jun
Abstract：Stroke is the leading cause of disability and death among adults in China,with more than 80%of strokes being ischemic strokes.Cerebral ischemia-reperfusion injury is a common cause of disability and death in patients with ischemic strokes.Currently,the clinical drugs targeting cerebral ischemia-reperfusion injury mainly include free radical scavengers,calcium ion antagonists,and excitatory amino acid antagonists,with unsatisfactory effects.In recent years,more and more researchers have begun to try using stem cells for treatment of cerebral ischemia-reperfusion injury,but animal experiments have found that the survival rate of transplanted stem cells in the brain is low,and very few stem cells can differentiate into neurons.Surprisingly,studies have found that stem cells can exert neuroprotective effect through paracrine exosomes.However,natural exosomes have poor targeting ability,and engineered exosomes with active targeting ability to neural cells have been developed.This review summarizes the progress in the neuroprotective effect of mesenchymal stem cell-derived exosomes on cerebral ischemia-reperfusion injury.
Keywords：Ischemic strokeIschemia-reperfusion injuryMesenchymal stem cellsExosomes
Publication Date：2024-03-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 177-180 )