Expression of KDELR2 in glioma tissues and its clinical significance:an analysis based on tissue microarray technology

ZHANG Jiao; HUANG Chun-hai; MAO Hui

doi:10.13798/j.issn.1009-153X.2024.03.006

Abstract：Objective To investigate the expression of KDELR2 in glioma tissues and its relationship with clinical and pathological features,and prognosis of glioma patients.Methods The HBraG180Su01 tissue microarray was selected as the experimental specimen,and their clinical data were collected.Immunohistochemical staining was used to detect the expression of KDELR2 in glioma tissues,and the relationships between KDELR2 expression level and clinical and pathological features,and prognosis of glimoa patients were analyzed.Results A total of 165 glioma cases were finally included.Immunohistochemical staining showed that KDELR2 was mainly located in the cytoplasm of glioma cells.The positive rate of KDELR2 expression in glioma tissues was as high as 98.18%.KDELR2 expression level was significantly correlated with WHO grade,recurrence status,and PDL1 expression,patients'age,and survival status(P<0.05),but not significantly correlated with patients'gender,and expression levels of Ki-67 and EGFR(P>0.05).Cox proportional hazards regression risk model analysis showed that high expression of KDELR2 was an independent risk factor for poor survival of glioma patients(P<0.05).Kaplan-Meier survival curve analysis showed that the overall survival and progression-free survival of patients with high expression of KDELR2 were significantly shorter than those with low expression of KDELR2(P<0.05).Conclusions KDELR2 is highly expressed in gliomas,is significantly correlated with WHO grade,tumor recurrence,and patients'prognosis.Our results suggest that KDELR2 may be a potential target for therapy of gliomas.