Microsurgical treatment of intracranial solitary fibrous tumors:report of 31 cases
QUAN Wei
HU Jun-xian
ANZAIER Aihemaiti
YANG Gui-fang
CHEN Jin-cao
ZHANG Jie
LI Zhi-qiang
Abstract：Objective To investigate the clinical features,imaging characteristics,pathological features,and microsurgical techniques and outcomes of intracranial solitary fibrous tumors(SFTs).Methods The clinical data of 31 patients with intracranial SFTs who underwent microsurgery from August 2014 to July 2023 were retrospectively analyzed.Results Of these 31 patients with intracranial SFTs,17 were male and 14 were female;the age ranged from 16 to 65 years;17 patients underwent the first surgery,and 14 underwent the secondary surgery;the clinical manifestations were mainly non-specific symptoms such as dizziness and headache;most SFTs had the imaging characteristics of well-defined borders,slightly low T1 signals,high T2 signals,and high T2 FLAIR signals;14 cases(45.2%)showed obvious peritumoral edema;the contrast-enhanced MR T1 iamges showed uniform enhancement in 18 cases(58.1%)and non-uniform and ring-like enhancement in 12 cases(38.7%).Total resection of tumor was achieved in 25 patients(80.6%)and subtotal in 6(19.3%).Postoperative pathological examination showed that positive expression of STAT6 was found in all 31 patients(100%),positive CD34 in 29 patients(93.5%),positive Vimentin in 20 patients(64.5%),and positive Bcl-2 in 8 patients(25.8%);the Ki-67 positive rate ranged from 2%to 30%,with a mean of(11±7)%,and the positive rate increased with the increase of tumor pathological grade.Nine patients were lost to follow-up,and 22 patients were successfully followed up for 6～80 months,with a mean of(35.0±23.8)months;three patients died,and the remaining 19 patients were alive.Conclusions Peritumoral edema is common in intracranial STFs,and the tumors may show non-uniform enhancement or ring-like enhancement on contrast-enhanced MR T1 images.Pathological examination is necessary for the diagnosis of SFTs.SFTs are prone to recurrence and may spread throughout the body.Early diagnosis and surgery at an early stage can help improve the prognosis of the patients with intracranial SFTs.
Keywords：Intracranial solitary fibrous tumorHemangiopericytomasMicrosurgeryEfficacy
Publication Date：2024-03-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 129-134 )